After two years, the Cleveland Browns meet the San Francisco 49ers on November 30th, 2025. There have always been fireworks when it's these two, like the Browns taking a close 19-17 victory in 2023. Before that, the 49ers dominated the game in a 31-3 win. Now focusing on the 2025 game, there have been some important updates regarding the players you must know. 

There are two players from the 49ers who did not enter the practice on Wednesday, Christian McCaffrey and Trent Williams.

Now, McCaffrey has 217 carries for 796 yards and scored 7 rushing touchdowns in 12 games this season. He is one of the best RBs this season, but 49ers fans will be happy to note he's not on the injury report. 

For the Cleveland Browns, a lot of players were limited in practice, including Devin Bush, Maliek Collins, Grant Delpit, Ronnie Hickman, and Myles Garrett.

Garrett has 33 solo tackles, 11 assists, and 18.0 sacks in 11 games this season, so his being limited in practice might also ring a bell for Browns’ fans, especially since he won the Defensive Player of the Week for his performance against the Raiders.

Maliek Collins has had 15 solo tackles, 9 assists, 6.5 sacks, and 1 fumble recovery in 11 games this season, and while his name might also worry the fans, no injury has been reported on him either.

However, there are a few surprises on the list. Let's dive right into it.

Cleveland Browns Injury Report

• CB Tyson Campbell - Hip - Limited
• TE Brenden Bates - Ankle - DNP
• QB Dillon Gabriel - Concussion - Full
• RB Jerome Ford - Hamstring - Limited
• DT Adin Huntington - Quad - DNP
• LB Carson Schwesinger - Ankle - Limited
• TE David Njoku - Knee - Limited
• CB Denzel Ward - Migraine - DNP
• DE Alex Wright - Quad - DNP
• WR Jamari Thrash - Foot - Limited

San Francisco 49ers Injury Report

• DT Sam Okuayinonu - Ankle - DNP
• LB Tatum Bethune - Ankle - DNP
• LB Luke Gifford - Hip, calf - Limited
• DE Robert Beal Jr. - Concussion - Full
• K Eddy Pineiro - Right hamstring - DNP
• OT Dominick Puni - Shoulder - Full
• WR Ricky Pearsall - Knee - Full
• QB Brock Purdy - Toe - Full

Written by

Reyansh Dubey

Edited by

Siddharth Shirwadkar